Furosemide Injection is a potent loop diuretic which is a derivative of anthranilic acid.
Chemical Name: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid. Furosemide is pharmacodynamically characterized by the following:
1) Administered intramuscularly, it begins to act in about 30 minutes, and diuretic response is produced. When administered intravenously, the response is in about 5 minutes.
2) Is a loop diuretic which inhibits the reabsorption of sodium and chloride at the ascending loop of Henle in the kidneys, enhancing water excretion.
3) A dose-response relationship and a ratio of minimum to maximum effective dose range greater than tenfold.
4) A high degree of efficacy, low inherent toxicity and a high therapeutic index.